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陳小明

博士、教授、碩士生導(dǎo)師

 教育背景、工作經(jīng)歷

2024-至今            蘭州大學(xué)化學(xué)化工學(xué)院、功能有機(jī)分子化學(xué)國家重點(diǎn)實(shí)驗(yàn)室，教授

2019-2024           蘭州大學(xué)化學(xué)化工學(xué)院、功能有機(jī)分子化學(xué)國家重點(diǎn)實(shí)驗(yàn)室，青年研究員

2017-2019           北京大學(xué)深圳研究生院，助理研究員

2015-2017           北京大學(xué)深圳研究生院 (導(dǎo)師: 翟宏斌)，博士后

2009-2015           蘭州大學(xué)，有機(jī)化學(xué)專業(yè)，理學(xué)博士

2003-2007           西北大學(xué)，應(yīng)用化學(xué)專業(yè)，理學(xué)學(xué)士 

·  榮譽(yù)獎勵

2023                     Thieme與中國化學(xué)會有機(jī)合成新銳獎

·  研究興趣

天然產(chǎn)物全合成以及合成導(dǎo)向的方法學(xué)研究

·  代表成果

1. Total Synthesis of (±)-Rubriflordilactone A. Zheng Xudong, Guo Xinlong, Wang Hongyu, Zhou Pan-Pan, Chen Xiaoming*. J. Am. Chem. Soc. 2024, 146, 7198-7203.

2. Enantiocontrolled Total Synthesis of (?)-Retigeranic Acid A. Chen Xiaoming*, Yao Weidong, Zheng Hufeng, Wang Hongyu, Zhou Pan-Pan, Zhu Dao- Yong, Wang Shao-Hua*. J. Am. Chem. Soc. 2023, 145, 13549-13555.

3. Asymmetric Total Synthesis of (+)-Alstonlarsine A. Yao Jun-Jun, Ding Rui, Chen Xiaoming, Zhai Hongbin*. J. Am. Chem. Soc. 2022, 144, 14396-14402.

4. Asymmetric Total Synthesis of (+)-Mannolide C. Ao Qiaoqiao, Zhang Hai-Jun, Zheng Jingbin, Chen Xiaoming*, Zhai Hongbin*. Angew. Chem. Int. Ed. 2021, 60, 21267-21271.

5. Au-Catalyzed 1,3-Acyloxy Migration/Cyclization Cascade: A Direct Strategy toward the Synthesis of Functionalized Abietane-Type Diterpenes. Tianlu Zheng, Sizhan Liu, Chen-Yu Huo, Jing Li, Bowen Wang, Daping Jin, Fu Cheng, Xiaoming Chen*, Xiaoming Zhang, Xuetao Xu, and Shaohua Wang*. CCS Chemistry  2020, 2, 2795-2802.

6. Divergent total syntheses of (-)-daphnilongeranin B and (-)-daphenylline. Xiaoming Chen#, Haijun Zhang#, Xinkan Yang, Houqiang Lv, Xiaoru Shao, Cheng Tao, Huifei Wang, Bin Cheng, Yun Li, Jingjing Guo, Jing Zhang, and Hongbin Zhai*. Angew. Chem. Int. Ed. 2018, 130, 959-963.(#contributed equally)

7. Trifunctionalization of Allenes via Cobalt-Catalyzed MHP-Assisted C?H Bond Functionalization and Molecular Oxygen Activation.  Shengxian Zhai, Shuxian Qiu, Xiaoming Chen, Cheng Tao, Yun Li, Bin Cheng, Huifei Wang, and Hongbin Zhai*. ACS Catal. 2018, 8, 6645. 

8. Formal Synthesis of (±)-Aplykurodinone-1 through a Hetero-Pauson–Khand Cycloaddition Approach. Cheng Tao, Jing Zhang, Xiaoming Chen, Huifei Wang, Yun Li, Bin Cheng, and Hongbin Zhai*. Org. Lett. 2017, 19, 1056.

9. 2-(1-Methylhydrazinyl)pyridine as a reductively removable directing group in a cobalt-catalyzed C(sp2)–H bond alkenylation/annulation cascade. Shengxian Zhai, Shuxian Qiu, Xiaoming Chen, Jiang Wu, Hua Zhao, Cheng Tao, Yun Li, Bin Cheng, Huifei Wang, and Hongbin Zhai*.  Chem. Commun. 2017, 54, 98.

10. Total synthesis of (+)-gelsemine via an organocatalytic Diels-Alder approach.  Xiaoming Chen, Shengguo Duan, Cheng Tao, Hongbin Zhai*, and Fayang G. Qiu*. Nat. Commun. 2015, 6, 7204.